InhaltsangabeThe Gerhard Zbinden Memorial Lecture.- Molecular Basis of Halothane Hepatitis.- Plenary Lecture.- Receptor-Mediated Toxicity.- Animals as Models in Toxicology: Animal Welfare and Ethics.- Animal Burdens versus Human Benefits - How Should the Ethical Limits be Drawn for Use of Animals as Models in Toxicology?.- Behavior of Laboratory Animals under Unnatural Conditions.- The Impact of Stress and Discomfort on Experimental Outcome.- Priorities in the Development of Alternative Methodologies in the Pharmaceutical Industry.- Development and Strategic Use of Alternative Tests in Assessing the Hazard of Chemicals.- Ecotoxicological Risk Assessment.- Soil Ecotoxicological Risk Assessment: How to Find Avenues in a Pitch Dark Labyrinth.- Monitoring and Risk Assessment for Endocrine Disruptors in the Aquatic Environment: A Biomarker Approach.- Effects of Environmental Chemicals on Reproduction.- Developmental and Reproductive Toxicity of Persistent Environmental Pollutants.- Effects of the In Vitro Chemical Environment During Early Embryogenesis on Subsequent Development.- Influence of Hormones and Hormone Antagonists on Sexual Differentiation of the Brain.- Reproductive Effects from Oestrogen Activity in Polluted Water.- Effects of Chemical-Induced DNA Damage on Male Germ Cells.- Biomarkers of Exposure.- Animal Locomotor Behaviour as a Health Biomarker of Chemical Stress.- Markers of Exposure to Aromatic Amines and Nitro-PAH.- Hematological and Biochemical Parameters in Pollution-Exposed Mice.- Current Molecular Approaches in Toxicology.- Detection of Low Levels of DNA Damage Arising from Exposure of Humans to Chemical Carcinogens.- Chemoprevention.- Natural Antioxidants in Chemoprevention.- Development of In Vitro Models for Cellular and Molecular Studies inToxicology and Chemoprevention.- Bioavailability and Health Effects of Dietary Flavonols in Man.- Epidemiological Studies on Antioxidants, Lipid Peroxidation and Atherosclerosis.- Regulatory Immunotoxicology: The Scientist's Point of View.- Regulatory Immunotoxicology - The Scientist's Point of View: An Introduction.- Contact and Respiratory Allergy: A Regulatory Perspective.- Immunotoxicology: Extrapolation from. Animal to Man - Estimation of the In munotoxicologic Risk Associated with TBTO Exposure.- Regulating Immunotoxicity Evaluation: Issues and Needs.- Novel Issues of Risk Assessment of Chemical Carcinogens.- Biomarkers in Metabolic Subtyping - Relevance for Environmental Cancer Control.- Assessment of Animal Tumour Promotion Data for the Human Situation.- Use of Transgenic Mutational Test Systems in Risk Assessment of Carcinogens.- Assessing Toxicological Impacts in Life Cycle Assessment.- Complex Mixtures.- Risk Asssessment for Complex Chemical Exposure in Aquatic Systems: The Problem of Estimating Interactive Effects.- Exposure of Humans to Complex Chemical Mixtures: Hazard Identification and Risk Assessment.- Receptor Mediated Toxic Responses.- Peroxisome Proliferator-Activated Receptor-Alpha and the Pleiotropic Responses to Peroxisome Proliferators.- Excitotoxicity in the Brain.- New Frontiers in Human and Ecological Toxicology: Determining Genetic vs. Environmental Causes of Susceptibility.- Variability in the Response of Daphnia Clones to Toxic Substances: Are Safety Margins Being Compromised?.- Sources and Implications of Variability in Sensitivity to Chemicals for Ecotoxicological Risk Assessment.- Polymorphism in Glutathione S-Transferase Loci as a Risk Factor for Common Cancers.- Population Responses to Contaminant Exposure in Marine Animals: Influences of Genetic Diversity Measured as Allozyme Polymorphism.- Extrahepatic Metabolism in Target Organ Toxicity.- The Use of Transgenic Animals to Assess the Role of Metabolism in Target Organ Toxicity.- Extrahepatic Cytochrome P450: Role in In Situ Toxicity and Cell-Specific Hormone Sensitivity.- Expression of Xenobiotic-Metabolizing Cyto chrome P450s in Human Pulmonary Tissues.- Comparison of GST Theta Activity in Liver