The first symposium of the working group on experimental urology of the German Society of Urology was held in Cologne in 1972. It was meant to be a platform to present and, in particular, to discuss experimental studies developing new diagnostic and therapeutic approaches, and to promote in novation in urology in Germany. This plan was well received, and during the last 16 years both the number of participants from other European and overseas countries and the number and quality of presentations have been continuously increasing. At the most recent meeting, held in Aachen in 1988, new data were presented on renal cell cancer, andrology, prostatic cancer and adenoma, bladder cancer, urinary diversion, urodynamics, renal pathophysiology, transplantation and the pathogenesis and treatment of urolithiasis. The present book contains 44 of the 109 papers given at the Aachen meeting, covering both basic and clinical research. It will be of eminent interest to all scientifically minded urologists, oncologists, neurophysiolo gists, endocrinologists, and pathologists because it is a synopsis of all the major scientific research currently being conducted in urology in Europe. There are no other books available which offer as comprehensive a cover age of recent experimental issues in urology. The aim of the series Inves tigative Urology is to demonstrate the continuous development of research in urology and to encourage all colleagues interested in experimental urol ogy to continue their important activities and create new international co operation.

InhaltsangabeI. Renal Cancer.- Biological Markers in the Evaluation of Prognosis in Patients with Renal Cell Carcinoma.- Comparison of Human Normal Renal Cells and Malignant Renal Cells In Vivo and In Vitro Using Cytological, Cytochemical, and Immunocytochemical Methods.- Growth and Cell Proliferation of Human Renal Cell Carcinomas Xenografted into BALB/c nu/nu Mice.- Expression of Epidermal Growth Factor Receptors on Renal Cell Carcinomas.- In Vitro Sensitivity of Three Human Renal Tumor Xenografts Towards Tumor Necrosis Factor and Alpha and Gamma Interferon.- Water-Jet Cutting: A New Technique for Selective Parenchymal Surgery of the Kidney.- II. Andrology and Testicular Cancer.- Testicular Blood Supply with a View to Surgical Treatment.- Alteration of Penile Ultrastructure in Impotence: Morphology and Clinical Correlation.- The Erection Ring - A New Treatment Approach in Venogenic Erectile Dysfunction.- Inhibitory Presynaptic Alpha-Adrenoceptors in the Human Corpus Cavernosum.- Intratesticular Concentration of Etoposide: An Experimental Study.- III. BPH-Prostate Cancer.- Diagnostic Studies Using Human BPH Tissues Transplanted on Thymus-Dysplastic Mice.- Age-Dependency and Regional Distribution of Enkephalinergic Nerves in the Human Prostate.- Tumor Marker Characterization in the Serially Transplantable PC-EW Human Prostatic Carcinoma Line in Nude Mice.- IV. Bladder Cancer.- DNA Histogram of Invasive Bladder Carcinoma: Comparison of Flow Cytometry and Automated Image Analysis.- Automatic Identification of Bladder Tumor Cells by Multiple Parameters in Flow Cytometry.- Immunohistochemical and Functional Investigations of Gap Junctions in Human Bladder Carcinoma Cell Lines.- Investigations for a Point Mutation in the c-Ha-ras 1 Oncogene in the Genome of Bladder Carcinomas by Southern Blot Analysis.- Prevention of Hyperchloremic Acidosis Following Ureterosigmoidostomy: The Functional Rectal Bladder.- Tumors Experimentally Produced in a Rat Model for Carcinogenesis in Ureterosigmoidostomy.- Efficacy of Systemic Chemotherapy in Metastatic Murine Bladder Cancer.- Selective Arterial Chemoembolization of the Urinary Bladder with Reabsorbable cis-Platinum Microcapsules in the Dog Using a Double Balloon Embolization Catheter.- Tissue Concentration of Chloraluminum-Phthalocyanine in Xenotransplanted Human Bladder Cancer.- Biological Effects of Recombinant Human Tumor Necrosis Factor on Human Bladder Cancer Cells.- Influence of Immunomodulation on Chemically Induced Bladder Tumors.- Effects of High Energy Shock Waves on BBN-Induced Bladder Tumors in Rats.- V. Urodynamics.- Papaverine in Human Bladder Muscle.- On the Locational Dependency and Diuresis Dependency of the Ureteral Dynamic: An Experimental Study in the Endoureteral Simultaneous Measurement of Pressure and Developed Force.- Detrusor Contractility and Its Relationship to Different Degrees of Tension.- VI. Kidney Trauma, Pathophysiology, Urolithiasis.- Renal Kinematics During Experimental Impact.- Improvement of In Situ Renal Protection Against Complete Ischemia Through the Replacement of Chloride by Aspartate in the HTK Solution of Bretschneider.- Investigations on the Crystallization Tendency in Urine with AC-Impedance Measurements and Cyclic Voltammetry.- Autoradiographic Study of Oxalate in Rats.- Lactose-Induced Urolithiasis in the Rat.- Investigation of Annual Rhythms for the Excretion of Calcium, Oxalic Acid, and Uric Acid in the 24-h Urine.- Calcium Binding by Various Brans: In Vitro Experiment with 45Ca.- Application of High-Performance Liquid Chromatography for Determination of Cysteine and Cystine in Urine.- Pathological-Anatomical Renal Alterations Following Application of Extracorporeally Produced Piezoelectric Shock Waves (Wolf-Piezolith): A Laboratory Animal Research Study.- The Effect of Shock Wave Exposure on Kidney Function in Dogs.- Urinary Proteins as Parameters of Renal Functional Changes After Extracorporeal Shock Wave Lithotripsy.- Changes in Blood and Urine Chemical P