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Adhesion Molecules: Function and Inhibition

Progress in Inflammation Research

Erschienen am 16.08.2007, 1. Auflage 2007
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Bibliografische Daten
ISBN/EAN: 9783764379742
Sprache: Englisch
Umfang: xiv, 309 S., 22 s/w Illustr., 1 farbige Illustr.,
Einband: gebundenes Buch

Beschreibung

InhaltsangabeCapture and rolling.- P-selectin glycoprotein ligand-1 (PSGL-1).- L-selectin-mediated leukocyte adhesion and migration.- P- and E-selectin.- Firm adhesion.- Endothelial ICAM-1 functions in adhesion and signaling during leukocyte recruitment.- ?4-integrins: structure, function and secrets.- VCAM-1 and its functions in development and inflammatory diseases.- Lymphocyte function-associated antigen-1 (LFA-1) and macrophage antigen-1 (Mac-1): Cooperative partners in leukocyte emigration and function.- Transendothelial migration.- PECAM: Regulating the start of diapedesis.- Role of ?6?1 integrin in leukocyte adhesion and transmigration.- Vascular adhesion protein-1 (VAP-1).- The role of endothelial cell-selective adhesion molecule (ESAM) in neutrophil emigration into inflamed tissues.- Structure and function of JAM proteins.- Promises and limitations of targeting adhesion molecules for therapy.